Molecular Formula | C28H44N4O8 |
Molar Mass | 564.68 |
Density | 1.274±0.06 g/cm3(Predicted) |
Boling Point | 837.0±65.0 °C(Predicted) |
Appearance | Solid |
pKa | 12.65±0.70(Predicted) |
Storage Condition | 2-8°C |
biological activity | Mizagliflozin (KWA 0711) is a novel, potent and selective sodium glucose co-transporter 1 (SGLT1) the inhibitor, Ki value for human SGLT1 was 27 nM. The selectivity ratio for Mizagliflozin (Ki value for human SGLT2/Ki value for human SGLT1) was 303. Mizagliflozin also has potential applications to improve chronic constipation. |
Target | Value |
human SGLT1 (Cell-free assay) | 27 nM(Ki) |
Animal Model: | Male Wistar rats (rat model of low-fiber-diet-induced constipation) |
Dosage: | 3, 10, 30 mg/kg |
Administration: | Oral |
Result: | Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation. |